High-throughput Screening

HTS involves the rapid and automated testing of large numbers of biomaterials or biomaterial combinations, using a variety of cell-based assays. By using HTS, researchers can efficiently identify biomaterials that promote cell adhesion, proliferation, or differentiation, or that exhibit other desired properties, such as biocompatibility or biodegradability. By using advanced machine learning algorithms we aim to advance our understanding of cell-biomaterial interactions with potential applications in tissue engineering, drug delivery, and other fields.

Publications

Tuvshindorj, U., Trouillet, V., Vasilevich, A., Koch, B., Vermeulen, S., Carlier, A., Alexander, M., Giselbrecht, S., TruckenmĂĽller, R., de Boer, J. (2022) The Galapagos Chip platform for high-throughput screening of cell adhesive micropatterns. Small, https://doi.org/10.1002/smll.202105704

Vermeulen, S., Honig, F., Vasilevich, A., Roumans, N., Romero, M., Dede Eren, Aysegul, Tuvshindorj, U., Alexander, M., Carlier, A., Williams, P., Uquillas, J., de Boer, J. (2021) Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction. Advanced Materials, https://doi.org/10.1002/adma.202102084

Yang, L., Pijuan-Galito, S., Suk Rho, H., Vasilevich, A., Dede Eren, A., Ge, L., Habibovic, P., Alexander, M., de Boer, J., Carlier, A., van Rijn, P., Zhou, Q. (2021) High-throughput methods in the discovery and study of biomaterials and materiobiology. Chemical Reviews, https://doi.org/10.1021/acs.chemrev.0c00752

Vasilevich, A., Carlier, A., Winkler, D., Singh, S., de Boer, J. (2020) Evolutionary design of optimal surface topographies for biomaterials. Scientific Reports, 10(1):22160, https://doi.org/10.1038/s41598-020-78777-2

Vassey, M., Figueredo, G.P., Scurr, P., Vasilevich, A., Vermeulen, S., Carlier, A., Luckett, J., Beijer, N., Williams, P., Winkler, D., de Boer, J., Ghaemmaghami, A.M., Alexander, M.R. (2020) Immune modulation by design: using topography to control human monocyte attachment and macrophage differentiation. Advanced Science, https://doi.org/10.1002/advs.201903392