Kidney physiology and pathology

CKD is a progressive condition that can lead to kidney failure and a range of other health complications. We develop advanced computational models to simulate and analyze the complex processes that occur within the kidney, such as blood flow, toxin transport, and waste filtration, providing insights into how these processes are disrupted in CKD and how they can be improved.

Publications

King, J., Giselbrecht, S., Truckenmüller, R., Carlier, A. (2021) Mechanistic computational models of epithelial cell transporters – the adorned heroes of pharmacokinetics. Frontiers in Pharmacology – Drug Metabolism and Transport, https://doi.org/10.3389/fphar.2021.780620y

King, J., Mihaila, S., Ahmed, S., Truckenmüller, R., Giselbrecht, S., Masereeuw, R., Carlier, A. (2021) The influence of OAT1 density and functionality on indoxyl sulfate transport in the human proximal tubule: an integrated computational and in vitro study. Toxins, 13(10), https://www.mdpi.com/2072-6651/13/10/674

Swapnasrita, S., Carlier, A., Layton, A. (2022) Sex-specific computational models of kidney function in patients with diabetes. Frontiers in Physiology, https://doi.org/10.3389/fphys.2022.741121