Integrin Mechanobiology

Integrins are proteins that mediate cell-matrix adhesion and facilitate the transmission of mechanical forces between cells and their surrounding environment. We work on in silico models to improve our understanding of integrin mechanobiology with the ultimate aim of designing and engineering biomaterials that interact effectively with cells. 

Publications

Eroumé, K., Cavill, R., Stankova, K., de Boer, J., Carlier, A. (2021) Exploring the influence of cytosolic and membrane FAK activation on YAP/TAZ nuclear translocation. Biophysical Journal, https://doi.org/10.1016/j.bpj.2021.09.009

Karagöz, Z., Geuens, T., LaPointe, V.L.S., van Griensven, M., Carlier, A. (2021) Win, lose or tie: mathematical modeling of ligand competition at the cell-extracellular matrix interface. Frontiers in Bioengineering and Biotechnology, section Tissue Engineering and Regenerative Medicine, https://doi.org/10.3389/fbioe.2021.657244

Eroumé, K., Vasilevich, A., Vermeulen, S., de Boer, J., Carlier, A. (2021) On the influence of cell shape on dynamic reaction-diffusion polarization patterns. PLoS One, doi:10.1371/journal.pone.0248293

Karagöz, Z., Rijns, L., Dankers, P., van Griensven, M., Carlier, A. (2021) Towards understanding the messengers of extracellular space: computational models of outside-in integrin reaction networks. Computational and Structural Biotechnology Journal, 19:303-314, https://doi.org/10.1016/j.csbj.2020.12.025

Vermeulen, M., Roumans, N., Honig, F., Carlier, A., Hebels, D., Dede Eren, A., ten Dijke, P., Vasilevich, A., de Boer, J. (2020) Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells. Biomaterials, https://doi.org/10.1016/j.biomaterials.2020.120331